Endocrine Abstracts

A 71 year old woman presented with visual loss. MR scanning demonstrated a massive invasive pituitary adenoma. She had no features of endocrine dysfunction. 0900hrs cortisol was 278nmol/L. Haemorrhage limited transphenoidal surgery to biopsies. Postoperative CSF leak was repaired 3months later. Histology revealed a corticotroph adenoma on immunostaining.At endocrine follow-up, afternoon cortisol was 645nmol/L, and 875nmol/L fasting, falling after glucago...

The prevalence of primary hyperparthyroidism (PT) in the general population is 0.15%. The incidence in pregnancy is unknown; however primary hyperparathyroidism during pregnancy poses significant maternal and fetal complications. Complications to the mother include nephrolithiasis, bone disease and muscle weakness. Fetal complications include fetal loss, intrauterine growth retardation, postpartum neonatal tetany and permanent hypoparathyroidism. The symptoms of PT are similar...